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Gipg013 is a specific competitive antagonist with equally high potency across mouse, rat, dog and human GIP receptors (72)

Similar to AMPARs, the tetrameric structure of KARs features two conformationally distinct but chemically identical diagonal subunit pairs (A/C and B/D), with domain swapping occurring between the ATD and LBD layers (Meyerson et al., 2016

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It appears to reduce insulin resistance, helping cells respond better to insulin